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Origin and evolution of the transcribed repeated sequences of the Y chromosome lampbrush loops of Drosophila hydei

机译:蝇果蝇Y染色体画笔环转录重复序列的起源和进化。

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摘要

The molecular evolution and patterns of conservation of clones from four Y chromosome lampbrush loops of Drosophila hydei were investigated. Each loop contains a discrete family of transcribed repeats that are only slightly conserved even in the hydei subgroup species. Sequencing of clones from the four D. hydei loops indicates that all transcribed repeats evolved from A+T-rich elements of the genome. Evidence is presented that suggests a Y-specific family evolved as a result of the transposition of repeated sequences from an autosomal site to the Y chromosome with the concomitant acquisition of transcriptional activity and loss of non-Y sequences. The results support a structural role for the loops in shaping a spermatocyte-specific nuclear organization. Transcribed heterochomatic sequences could play a similar role in nuclear organization in many cell types.
机译:研究了果蝇四个Y染色体画笔环的克隆的分子进化和保守模式。每个环包含一个离散的转录重复家族,即使在hydei亚组物种中也只是稍微保守。从四个D. hydei环克隆的测序表明,所有转录的重复序列都是从基因组中富含A + T的元素进化而来的。提出的证据表明,由于重复序列从常染色体位点转移到Y染色体,伴随着转录活性的获得和非Y序列的丧失,Y特异家族得以进化。结果支持环在塑造精子细胞特异性核组织中的结构作用。转录的异源序列可以在许多细胞类型的核组织中发挥相似的作用。

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